Pump Inhibitors and Risk of Hip Fracture

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Postmenopausal PPI Use May Increase Risk Of Hip Fracture.

MedPage Today (2/1, Walsh) reports that according to a National Institutes of Health-funded study published online in the BMJ, “postmenopausal women who use proton pump inhibitors (PPIs) regularly are at increased risk for hip fracture, particularly if they have ever smoked.” In fact, “the risk of hip fracture was increased by 35% among women who used these drugs for at least two years, compared with women who never used them (age-adjusted HR 1.35, 95% CI 1.12 to 1.62, P<0.01 for trend)." What's more, "the risk for fracture rose by more than 50% among women with a history of smoking (multivariate HR 1.51, 95% CI 1.20 to 1.91)," the study found. For the study, researchers "collected data on almost 80,000 postmenopausal women," HealthDay (2/1, Reinberg) reports. "Over the course of eight years, from 2000 to 2008, almost 900 hip fractures occurred -- a 35 percent increased risk for women using PPIs compared to women who didn't take the drugs." In other words, "in absolute terms, the risk of hip fracture works out to about 2.02 fractures for every 1,000 person-years for those taking PPIs, compared with 1.51 fractures per 1,000 person-years." Also covering the story are BBC News (2/1) and the UK's Daily Mail (2/1, Borland).

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